When you stop taking sermorelin, your body's growth hormone levels gradually return to their baseline. This transition typically happens over several weeks as your pituitary gland adjusts to functioning without the external stimulus.
The first week after stopping sermorelin, you might not notice significant changes. Your body still has some residual effects from the treatment.
By weeks 2-4, growth hormone production begins to decrease, returning to your natural levels. This is when subtle changes might become noticeable.
After 1-2 months, most people find their hormone levels have completely returned to pre-treatment baselines.

Many physical and performance changes may occur when you stop sermorelin:
- Decreased muscle mass: Without the extra growth hormone stimulation, maintaining muscle gains becomes harder. If you're looking for alternatives, you might want to check out the best peptides for muscle growth to maintain your progress.
- Reduced fat burning: Your metabolism may slow down slightly, making fat loss more challenging.
- Sleep quality changes: Some people report changes in sleep patterns as hormone levels readjust.
- Energy decreases: You might notice lower energy levels or reduced exercise performance.
- Skin changes: Improvements in skin elasticity and texture may gradually diminish.
If you still have unused sermorelin, knowing how to store peptides properly is important to maintain their effectiveness for future use.