The most common reason for lack of weight loss on semaglutide is insufficient dosage. Your current dose may be too low to trigger the full weight loss effects.
Semaglutide works best when properly titrated up to an effective dose.
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Doctors typically start patients on a low dose and increase it slowly to minimize side effects. This careful approach means you might not reach a therapeutic dose for many weeks or months.
During this time, weight loss may be minimal or nonexistent.
Some patients cannot increase to higher, more effective doses because of side effects like nausea, vomiting, or diarrhea. If side effects prevent you from increasing your dose, you might not achieve significant weight loss.
While semaglutide reduces appetite, it works best when combined with proper diet and exercise. If your eating habits haven't changed or you're consuming high-calorie foods, the medication's effects may be limited.
Each person responds differently to medications. Some people experience dramatic weight loss on semaglutide, while others have a more modest response. Your personal biology affects how you respond to the medication.
Certain medical conditions or medications can interfere with weight loss. Conditions like hypothyroidism, polycystic ovary syndrome, or insulin resistance might make weight loss more difficult even with semaglutide.
If you're not losing weight on semaglutide:
- Talk to your doctor about your current dose and whether it can be safely increased
- Be patient with the titration schedule
- Follow a balanced, calorie-controlled diet
- Incorporate regular physical activity
- Track your food intake to identify hidden calories
- Consider consulting with a registered dietitian
For those exploring alternatives, the best peptides for weight loss might offer different options. Some patients who don't respond well to semaglutide find success with other medications.
If semaglutide isn't working for you, ask your doctor about other GLP-1 medications or combined approaches.
For example, learning how to mix retatrutide peptide for weight loss might be worth exploring, as newer medications target multiple hormonal pathways.
